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-- Fatal error during HotSync (http://discussion.visorcentral.com/vcforum/showthread.php?threadid=1626)

Does any one know what a "MemoryMgrNew.c.Line 4128 Invalid Handle" errror is? I have an iMac and after several uneventful HotSyncs (although it always takes several minutes before synchronization starts), I can no longer sync because of fatal errors with the above message.
I use a lot of 3rd party applications and Hacks, but have not added any new ones to blame them for the problem.
Any suggestions?

Thank you